Association Between Time in Targeted Blood Glucose Range With All-Cause Mortality in Critically Ill Patients With Heart Failure
Authors' conclusion
Higher TTBR is independently associated with lower mortality in critically ill HF patients, supporting its potential role as a prognostic indicator of glycemic control in this setting.
Study context
- Population
- Critically ill heart failure (HF) patients in ICU, MIMIC-IV database; mean age 71.77; TTBR = % of time glucose 70–139 mg/dL
- Participants
- 5,396 patients
- Exposure
- TTBR quartiles
- Outcome
- All-cause mortality
Methodological detailsMIMIC-IV database
- MIMIC-IV database
Main finding
As reported in the abstract
Mortality
Each group vs Q1Hazard ratio (95% CI)P value
Q3
0.64(0.51–0.79)
P = 0.004Q4
0.58(0.47–0.72)
P = 0.003- Mortality decreased progressively across TTBR quartiles
- P < 0.001
- TTBR as continuous variable (model 3), HR
- 0.98 (95% CI 0.98-0.99, P < .001)
Observational data: associations, not effects.
Further findings
Discrimination of fully adjusted model
- AUC
- 0.77 (95% CI: 0.73-0.81)
Subgroups
- Protective effect of higher TTBR consistent across most subgroups
Original publication
Association Between Time in Targeted Blood Glucose Range With All-Cause Mortality in Critically Ill Patients With Heart Failure. Endocr Pract. Published 11 August 2025. doi:10.
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