Diabetic Macular Edema Is Predictive of Renal Failure in Patients With Diabetes Mellitus and Chronic Kidney Disease
Authors' conclusion
Statistically significant 5-year increased risks of ESRD, dialysis, and renal transplantation were observed in patients with concurrent DME. Therefore, close monitoring and follow-up of the renal function in DM patients with DME are necessary and strongly recommended.
Study context
- Population
- Patients with diabetes mellitus (DM) and chronic kidney disease (CKD), TriNetX network (120 healthcare organizations; EMRs of ≈90 million patients reviewed)matched cohort
- Exposure
- Diabetic macular edema (DME) vs non-DME
- Outcome
- New-onset end-stage renal disease (ESRD)
Methodological detailsmatched, multicentre (120 healthcare organizations, TriNetX network)
- Matched
- Multicentre (120 healthcare organizations, TriNetX network)
Main finding
As reported in the abstract
New-onset ESRD
- Significantly higher risk of end-stage renal disease (ESRD), dialysis and renal transplantation in DME vs non-DME
- Subgroup analyses consistent irrespective of follow-up duration, initial eGFR or HbA1c
- Matched cohort
Observational data: associations, not effects.
Secondary outcomes
- Lower risk of all-cause mortality in DME vs non-DME
Original publication
Diabetic Macular Edema Is Predictive of Renal Failure in Patients With Diabetes Mellitus and Chronic Kidney Disease. J Clin Endocrinol Metab. Published 6 October 2023. doi:10.
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