Anti‐ VEGF monotherapy versus anti‐ VEGF therapy combined with laser or intravitreal glucocorticoid therapy for diabetic macular edema: A Bayesian network meta‐analysis
Authors' conclusion
Anti-VEGF monotherapy and anti-VEGF therapy combined with laser or intravitreal glucocorticoid therapy exerted comparable effects. However, the ranking chart recommends anti-VEGF therapy combined with laser therapy. Meanwhile, anti-VEGF therapy combined with intravitreal glucocorticoid therapy did not demonstrate significant benefits.
Study context
- Population
- Patients with diabetic macular edema (DME) in RCTs (PubMed, Embase, Cochrane Library)21 RCTs, eyes
- Participants
- 1,798 patients
- Comparison
- Anti-VEGF monotherapy vs anti-VEGF combined with laser or intravitreal glucocorticoid
- Outcome
- Mean change from baseline in best-corrected visual acuity (BCVA) and central macular thickness (CMT)
- Follow-up
- 6 and 12 months
Methodological detailsfixed-effects model
- Fixed-effects model
Pooled result
As reported in the abstract
Mean BCVA and CMT changes from baseline
- Anti-VEGF monotherapy and anti-VEGF combined with laser or intravitreal glucocorticoid did not significantly change mean central macular thickness (CMT) and best-corrected visual acuity (BCVA)
- MD with 95% CrI
- Fixed-effects model
Further pooled results
Simulation-based ranking for mean BCVA change: anti-VEGF + laser likely most effective
- Anti-VEGF + laser most effective at 6 months
- 70.7515%
- Anti-VEGF + laser most effective at 12 months
- 70.9315%
Simulation-based ranking for mean CMT change: anti-VEGF + laser likely most effective
- Anti-VEGF + laser most effective at 6 months
- 83.6350%
- Anti-VEGF + laser most effective at 12 months
- 74.7730%
Original publication
Anti‐ VEGF monotherapy versus anti‐ VEGF therapy combined with laser or intravitreal glucocorticoid therapy for diabetic macular edema: A Bayesian network meta‐analysis. Diabetes Obes Metab. Published 20 February 2025. doi:10.
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