Correlation between surrogate indicators of insulin resistance and all-cause mortality in patients with severe hemorrhagic stroke: a multicenter retrospective cohort study in the United States
Authors' conclusion
In conclusion, insulin resistance surrogate markers were significantly associated with all-cause mortality in critically ill HS patients. Despite their weak-to-moderate discriminative performance, these indices may serve as auxiliary prognostic references for risk stratification. Clinical application of these indicators is expected to optimize therapeutic strategies and disease progression management. Furthermore, this study enriches current evidence regarding the association between insulin resistance surrogate markers and hemorrhagic stroke, and clarifies their roles in predicting mortality across different stroke subtypes.
Study context
- Population
- Intensive care unit (ICU)-admitted patients with severe hemorrhagic stroke (intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH)) identified by ICD-9/10 codes, eICU-CRD database, US
- Participants
- 1,538 patients
- Exposure
- Quartiles of insulin resistance (IR) surrogate markers
- Outcome
- In-hospital mortality
Methodological detailsmulticenter, eICU-CRD database
- Multicenter
- eICU-CRD database
Main finding
As reported in the abstract
Overall in-hospital all-cause mortality
26.59%
Observational data: associations, not effects.
Further findings
Effect modification
- No significant effect modification in interaction analyses
Predictive accuracy (ROC)
- TyG exhibited the highest predictive accuracy
Original publication
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