Macular microcirculation changes in incident type 2 diabetes without fundus Photography-Detectable diabetic Retinopathy: A 6-Year nested Case-Control study
Authors' conclusion
Incident T2DM eyes showed greater decline in DCP VD than controls without fundus photography-detectable DR.
Study context
- Population
- Participants who developed incident T2D during follow-up without fundus photography-detectable diabetic retinopathy (DR), and age-matched controls without diabetes; 6 x 6 mm macular OCT angiography at both visits40 T2DM participants
- Comparison
- Incident T2D without DR vs controls without diabetes
- T2DMn = 68 eyes
- Controlsn = 204 eyesreference
- Outcome
- 6-year macular microcirculation changes: VD in SCP and DCP, foveal avascular zone-related parameters, foveal density 300
- Follow-up
- 6 years
Methodological details6-year longitudinal, age-matched controls
- 6-year longitudinal
- Age-matched controls
Main finding
As reported in the abstract
- Both groups showed decreases in superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel density (VD) over 6 years
- Reductions in DCP VD greater in T2DM eyes than controls
- T2DM vs Controls: all P < 0.05
- Generalized estimating equations
Observational data: associations, not effects.
Further findings
Microvascular abnormalities in incident T2DM eyes · 6 years
- Diabetic eyes that developed microvascular abnormalities
- 23
- Microvascular abnormalities independently associated with longer diabetes duration
Original publication
Macular microcirculation changes in incident type 2 diabetes without fundus Photography-Detectable diabetic Retinopathy: A 6-Year nested Case-Control study. Diabetes Res Clin Pract. Published 26 June 2026. doi:10.
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