Increased fatty acid-binding protein 4 levels are associated with the risk of developing retinopathy in type 2 diabetes mellitus patients
Main finding · DR risk with FABP4 above cutoffResult — go to the resultOdds ratio 6.394 95 % CI 3.18–13.58Authors' conclusion
The FABP4 level is associated with DR severity and has the potential as a serum biomarker for DR prediction.
Study context
- Population
- Patients with T2DM and healthy controls; Diabetic retinopathy (DR) severity by fundus fluorescence angiography
- Participants
- 275 patients
- Exposure
- Serum FABP4 above vs below cutoff
- Healthy controlsn = 78
- T2DMn = 197
- Outcome
- Association between serum FABP4 levels and risk of DR
Main finding
DR risk with FABP4 above cutoff
Odds ratio
6.394
95 % CI 3.18–13.58
P < 0.001
FABP4 >20.57 ng/mlvs FABP4 ≤20.57 ng/ml
OR 6.394 (95 % CI 3.18–13.58); P < 0.001
As reported in the abstract
- FABP4 correlated positively with DR severity
- r = 0.328, P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | OR (95 % CI) | P value | |
|---|---|---|---|
| PDR risk with FABP4 above cutoffFABP4 >24.40 ng/mlvs FABP4 ≤24.40 ng/ml | 4.686 (1.907–12.34) | P = 0.001 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Increased fatty acid-binding protein 4 levels are associated with the risk of developing retinopathy in type 2 diabetes mellitus patients. Diabetes Metab. Published 18 April 2025. doi:10.
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