Geriatric nutritional risk index predicts incident kidney failure with replacement therapy among patients with biopsy-proven diabetic nephropathy
Main finding · Incident KFRTResult — go to the resultHazard ratio 3.13 95 % CI 1.74–5.61Authors' conclusion
Among patients with DN, lower GNRI was associated with incident KFRT even after adjustment for muscle mass-independent kidney function markers. Further research is warranted to clarify whether nutritional improvement can attenuate kidney function decline.
Study context
- Population
- Patients with biopsy-proven diabetic nephropathy at Nara Medical University Hospital; Geriatric nutritional risk index (GNRI) at time of kidney biopsy
- Participants
- 405 patients
- Exposure
- Lower vs higher GNRI
- Outcome
- Kidney failure with replacement therapy (KFRT)
- Follow-up
- Median 6.7 years
Methodological detailsobservational, single-centre
- Observational
- Single-centre
Main finding
Incident KFRT
Hazard ratio
3.13
95 % CI 1.74–5.61
Lower GNRIvs Higher GNRI
HR 3.13 (95 % CI 1.74–5.61)
As reported in the abstract
- Patients developing kidney failure with replacement therapy (KFRT)
- 99
Observational data: associations, not effects.
Further findings
KFRT after additional adjustment for muscle mass-independent kidney function markers (serum β2-microglobulin or muscle mass-adjusted estimated glomerular filtration rate (eGFR))
- Association of lower GNRI with KFRT remained robust
Original publication
Geriatric nutritional risk index predicts incident kidney failure with replacement therapy among patients with biopsy-proven diabetic nephropathy. Diabetes Res Clin Pract. Published 23 August 2025. doi:10.
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