Fractional Excretion of Total Protein and Long‐Term Kidney Outcomes in Patients With Biopsy‐Proven Diabetic Nephropathy: The N‐ BDN Study
Authors' conclusion
FETP was independently associated with KFRT in patients with DN and may provide additional prognostic information beyond conventional proteinuria for risk stratification.
Study context
- Population
- Patients with biopsy-proven diabetic nephropathy (DN) at one institution, June 1981–December 2014; median age 59 years, 62.5% male, median eGFR 58.1 mL/min/1.73 m²97 developed KFRT
- Participants
- 376 patients
- Exposure
- Fractional excretion of total protein (FETP)-based vs proteinuria-based prediction model for KFRT
- Outcome
- Incremental prognostic value of adding FETP vs proteinuria to a baseline clinical model for predicting kidney failure requiring replacement therapy (KFRT)
- Follow-up
- Median 6.7 years
Methodological detailsobservational, single-centre
- Observational
- Single-centre
Main finding
As reported in the abstract
Prediction of KFRT
Each group vs proteinuria-based modelΔC-index (95% CI)
FETP-based model
0.021(0.002–0.039)
- FETP-based model
- Integrated discrimination improvement (IDI) 0.089 (95% CI 0.001–0.207)
Observational data: associations, not effects.
Original publication
Fractional Excretion of Total Protein and Long‐Term Kidney Outcomes in Patients With Biopsy‐Proven Diabetic Nephropathy: The N‐ BDN Study. Diabetes Obes Metab. Published 13 July 2026. doi:10.
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