C-reactive protein–triglyceride glucose index for the detection of the severity of coronary artery disease in different glucose metabolic states in patients with H-type hypertension
Authors' conclusion
CTI is an independently associated factor for coronary stenosis severity in patients with hypertension, particularly in those with H-type hypertension and comorbid diabetes.
Study context
- Population
- Hypertensive patients who underwent coronary angiography, across glucose metabolism statuses and H-type hypertension subgroups
- Participants
- 1,392 patients
- Exposure
- CTI tertiles
- Outcome
- CAD severity (Gensini score stenosis severity; multi-vessel CAD)
Main finding
As reported in the abstract
Association of CTI with CAD severity (adjusted)
CTIOdds ratio (95% CI)
Multi-vessel CAD
2.155(1.839–2.455)
Moderate-to-severe coronary stenosis
1.818(1.603–2.062)
- Linear dose-response relationship between CTI and coronary artery disease (CAD) severity (restricted cubic spline (RCS))
- P for non-linearity > 0.05
- Interaction between CTI and H-type hypertension on CAD severity
- P = 0.033
Observational data: associations, not effects.
Further findings
| Outcome | Fold increased risk (95% CI) | P value |
|---|---|---|
| Multi-vessel CAD, H-type hypertension with DM subgroupT3 vs T1 · adjusted for risk factors | 6.475 (1.693–24.773) | P = 0.006 |
Moderate-to-severe coronary stenosis in diabetes mellitus (DM)
- No association between CTI and moderate-to-severe coronary stenosis in patients with DM
Discrimination of CTI for multi-vessel CAD, H-type hypertension with DM
- AUC
- 0.712 (95% CI 0.619-0.804, P < 0.001)
- Highest across glucose metabolism subgroups
Original publication
C-reactive protein–triglyceride glucose index for the detection of the severity of coronary artery disease in different glucose metabolic states in patients with H-type hypertension. Cardiovasc Diabetol. Published 9 August 2026. doi:10.
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