Correlation between triglyceride glucose index and collateral circulation formation in patients with chronic total occlusion of coronary arteries in different glucose metabolic states
Authors' conclusion
TyG index was significantly associated with the risk of poor collateral circulation formation in patients with CTO, especially those with Pre-DM and DM.
Study context
- Population
- Patients with chronic total occlusion (CTO) lesion in ≥1 major coronary artery on coronary angiography, January 2020–December 2021
- Participants
- 681 patients
- Exposure
- Poor vs good collateral circulation formation; TyG index by glucose metabolic state
- Poor collateraln = 205
- Good collateraln = 476reference
- Normal glucose regulation (NGR)n = 139
- Prediabetes mellitus (Pre-DM)n = 218
- Diabetes mellitus (DM)n = 324
- Outcome
- TyG index and poor collateral circulation formation
Main finding
As reported in the abstract
TyG index independent risk factor for poor collateral circulation (logistic regression), OR (95% CI 3.323-7.839), P < 0.001
5.104
AUC of TyG index for predicting collateral circulation (95% CI 0.738-0.820), P < 0.001
0.779
Observational data: associations, not effects.
Further findings
TyG index and poor collateral circulation by glucose metabolic state
- Restrictive cubic spline: risk initially flat then increased rapidly in Pre-DM and DM, except NGR
- TyG index significantly associated with increased risk of poor collateral circulation in Pre-DM and DM
Original publication
Correlation between triglyceride glucose index and collateral circulation formation in patients with chronic total occlusion of coronary arteries in different glucose metabolic states. Cardiovasc Diabetol. Published 13 January 2024. doi:10.
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