Associations of the triglyceride-glucose index and atherogenic index of plasma with the severity of new-onset coronary artery disease in different glucose metabolic states
Authors' conclusion
The TyG index and AIP have significant associations with CAD. The TyG index had no association with CAD severity, regardless of glucose metabolic states. AIP exhibited a discernible link with CAD severity in NGR patients, but not in the pre-DM or DM populations. The TyG index and AIP have similar predictive values for new-onset CAD.
Study context
- Population
- Subjects undergoing first coronary angiography; glucose metabolic states normal glucose regulation (NGR), pre-diabetes mellitus (Pre-DM) and diabetes mellitus (DM) per WHO diabetes guidelines
- Participants
- 570 subjects
- Exposure
- Triglyceride-glucose (TyG) index and atherogenic index of plasma (AIP) vs coronary artery disease (CAD) presence and severity across glucose metabolic states (NGR, Pre-DM, DM)
- CADn = 431
- Non-CADn = 139reference
- Outcome
- CAD severity (single-vessel vs multi-vessel CAD)
Main finding
As reported in the abstract
- AIP significantly related to CAD severity in NGR patients
- P < 0.05
Observational data: associations, not effects.
Further findings
Association of TyG index and AIP with CAD
- TyG index and AIP independently correlated with CAD (logistic regression)
- both P < 0.05
Prediction of CAD (ROC)
- AUC of TyG index
- 0.682
- AUC of AIP
- 0.642
- P for both AUCs
- P < 0.001
- Optimal cut-off TyG index (Youden index: 0.305)
- 3.210
- Optimal cut-off AIP (Youden index: 0.246)
- 0.095
Original publication
Associations of the triglyceride-glucose index and atherogenic index of plasma with the severity of new-onset coronary artery disease in different glucose metabolic states. Cardiovasc Diabetol. Published 20 February 2024. doi:10.
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