Association between the stress hyperglycemia ratio and severity of coronary artery disease under different glucose metabolic states
Authors' conclusion
Our study indicated that SHR was significantly correlated with the risk of multi-vessel CAD and predicted CAD severity, especially in pre-DM and DM patients.
Study context
- Population
- Patients who underwent coronary angiography (CAG), October 2020 to May 2022; stratified by glucose metabolism status (normal glucose regulation (NGR), pre-diabetes mellitus (pre-DM), diabetes mellitus (DM))
- Participants
- 987 patients
- Exposure
- Stress hyperglycemia ratio (SHR) tertiles T2 and T3 vs T1
- Outcome
- Multi-vessel CAD (vs single-vessel CAD) on CAG
Main finding
As reported in the abstract
Risk of multi-vessel CAD
Adjusted risk (fold)
1.939
95% CI 1.341–2.804P < 0.001
T2
Adjusted risk (fold)
1.860
95% CI 1.272–2.719P = 0.001
T3
- SHR as continuous variable, independent risk factor for multi-vessel coronary artery disease (CAD) (OR)
- 4.047 (95% CI 2.137-7.663; P < 0.001)
Observational data: associations, not effects.
Further findings
Prediction of CAD severity by SHR (ROC)
- AUC for SHR
- 0.613
Multi-vessel CAD by glucose metabolism status
- SHR significantly correlated with increased risk of multi-vessel CAD in pre-DM and DM
Original publication
Association between the stress hyperglycemia ratio and severity of coronary artery disease under different glucose metabolic states. Cardiovasc Diabetol. Published 8 February 2023. doi:10.
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