Association between integrase strand transfer inhibitor use with insulin resistance and incident diabetes mellitus in persons living with HIV: a systematic review and meta-analysis
Pooled result · Incident DMResult — go to the resultRelative risk 0.80 95% CI 0.67–0.96Authors' conclusion
In conclusion, exposure to INSTIs was not associated with increased risk of DM, except in the African population.
Study context
- Population
- Persons living with HIV; studies published 1 January 2000 to 15 June 2022 (MEDLINE, Embase, Web of Science, ClinicalTrials.gov)13 studies for incident diabetes mellitus (DM)
- Participants
- 72,404 persons
- Comparison
- Integrase strand transfer inhibitors (INSTIs) vs other antiretroviral therapies (ART)
- Outcome
- Incident DM
Methodological detailsrandom-effects meta-analysis, 3 studies pooled for changes in HOMA-IR; 16 studies in total
- Random-effects meta-analysis
- 3 studies pooled for changes in HOMA-IR; 16 studies in total
Pooled result
As reported in the abstract
Relative risk
0.80
95% CI 0.67–0.96
INSTIsvs Other ARTs
RR 0.80 (95% CI 0.67–0.96)
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| Incident DM, RCTs only8 RCTs; I2=0% | 0.88 (0.81–0.96) | |
| Incident DM, INSTIsvs NNRTIsI2=0% | 0.75 (0.63–0.89) | |
| Incident DM, INSTIsvs PI-based therapyI2=27%; similar risk | 0.78 (0.61–1.01) | |
| Incident DM, studies with longer follow-upI2=24% | 0.70 (0.53–0.94) | |
| Incident DM, ART-naïve patientsI2=3% | 0.78 (0.65–0.94) | |
| Incident DM, African populationsI2=0%; increased risk | 2.99 (2.53–3.54) | |
| 0.20.5125Relative risk (log scale) |
- Incident DM, RCTs only — Reduced risk
- 22%
Original publication
Association between integrase strand transfer inhibitor use with insulin resistance and incident diabetes mellitus in persons living with HIV: a systematic review and meta-analysis. BMJ Open Diabetes Res Care. Published 8 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →