Increased Resting-State Functional Connectivity as a Compensatory Mechanism for Reduced Brain Volume in Prediabetes and Type 2 Diabetes
Authors' conclusion
Cognition was associated with greater brain volume and lower functional connectivity in T2DM. Increased functional connectivity may indicate a compensatory mechanism for reduced brain volume that begins in the prediabetic phase.
Study context
- Population
- Population-based participants with NGM, prediabetes or T2DM who underwent structural MRI and cognitive testing2,145 also had functional MRI
- Participants
- 2,483 participants
- Exposure
- T2DM and prediabetes vs NGM
- NGMn = 569reference
- Prediabetesn = 1,353
- T2DMn = 561
- Outcome
- Brain volume and functional connectivity vs NGM
Methodological detailsstructural and functional MRI, multivariate linear regression
- Structural and functional MRI
- Multivariate linear regression
Main finding
As reported in the abstract
- T2DM: lower brain volume in a wide range of brain regions and stronger functional connectivity between bilateral thalamus and visual and default mode networks vs NGM
- Prediabetes: lower subcortical gray matter volume and subregions (bilateral thalamus, bilateral nucleus accumbens, right putamen) and stronger functional connectivity between right thalamus and visual network vs NGM
Observational data: associations, not effects.
Further findings
Association with cognition and between volume and connectivity
- Cognition associated with greater right thalamus volume and lower right thalamus–visual network functional connectivity
- Right thalamus–visual network functional connectivity associated with lower right thalamus volume
Original publication
Increased Resting-State Functional Connectivity as a Compensatory Mechanism for Reduced Brain Volume in Prediabetes and Type 2 Diabetes. Diabetes Care. Published 7 February 2023. doi:10.
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