Kidney measures and cerebral white matter hyperintensity severity in chronic kidney disease stratified by type 2 diabetes mellitus status
Authors' conclusion
Albuminuria and KDIGO risk category are associated with greater periventricular WMH severity regardless of T2DM status. Lower eGFR is more consistently linked to WMH severity in T2DM patients.
Study context
- Population
- Adults with chronic kidney disease (CKD) from the Taiwan Kidney Outcome (TAKO) cohort who underwent brain MRI between 2007 and 2021
- Participants
- 1,085 adults
- Exposure
- Kidney measures and white matter hyperintensity (WMH) severity, stratified by T2D status
- T2DMn = 615
- non-T2DMn = 470
- Outcome
- Fazekas-defined WMH severity
Methodological detailsmultivariable proportional odds regression, sensitivity analyses
- Multivariable proportional odds regression
- Sensitivity analyses
Main finding
As reported in the abstract
Periventricular WMH severity with albuminuria A3, by T2DM status
| Group | OR | 95 % CI | P |
|---|---|---|---|
| T2DM | 2.46 | 1.49-4.10 | P < 0.001 |
| non-T2DM | 2.11 | 1.27-3.51 | P = 0.004 |
OR
T2DM2.46
non-T2DM2.11
95 % CI
T2DM1.49-4.10
non-T2DM1.27-3.51
P
T2DMP < 0.001
non-T2DMP = 0.004
Observational data: associations, not effects.
Original publication
Kidney measures and cerebral white matter hyperintensity severity in chronic kidney disease stratified by type 2 diabetes mellitus status. Diabetes Res Clin Pract. Published 13 June 2026. doi:10.
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