Apolipoprotein B100 predicts cardiovascular and limb events in type 2 diabetes patients with chronic limb-threatening ischemia
Authors' conclusion
Elevated baseline ApoB100 independently predicted MACE, MALE, and composite events post-LER in T2DM-CLTI patients, substantially improving clinical risk models. Integrating ApoB100 into post-LER management algorithms could refine individualized therapeutic strategies, especially in patients with residual atherogenic risk despite optimal LDL-C control.
Study context
- Population
- T2D patients with chronic limb-threatening ischemia (CLTI) undergoing lower extremity revascularization (LER)
- Participants
- 167 patients
- Exposure
- Event vs no-event groups by baseline Apolipoprotein B100 (ApoB100)
- Outcome
- MACE, major adverse limb events (MALE) and composite endpoints predicted by baseline ApoB100
- Follow-up
- 12 months
Methodological detailsVisits at 1, 3, 6 and 12 months post-procedure
- Visits at 1, 3, 6 and 12 months post-procedure
Main finding
As reported in the abstract
Baseline ApoB100 as predictor of composite events, MACE and MALE
- Composite events
- 49.1%
- Major adverse cardiovascular events (MACE)
- 24%
- Major adverse limb events (MALE)
- 35.3%
- ApoB100, composite event vs no event (p < 0.01)
- 62.1 vs 38.0 mg/dL
- ApoB100, MACE vs no MACE (p < 0.01)
- 66.1 vs 44.4 mg/dL
- ApoB100, MALE vs no MALE (p < 0.01)
- 61.0 vs 42.4 mg/dL
- Multivariable OR per mg/dL ApoB100, composite
- 1.14 (95% CI 1.08-1.20, p < 0.01)
- Multivariable OR, MACE (p < 0.01)
- 1.10
- Multivariable OR, MALE (p < 0.01)
- 1.05
- AUC of ApoB100
- 0.86 (95% CI 0.80-0.91)
- Optimal ROC-derived cut-off
- 56.6 mg/dL
- AUC gains adding ApoB100 to conventional risk factors (all p < 0.01)
- 0.08-0.15
Observational data: associations, not effects.
Original publication
Apolipoprotein B100 predicts cardiovascular and limb events in type 2 diabetes patients with chronic limb-threatening ischemia. Cardiovasc Diabetol. Published 12 June 2026. doi:10.
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