Development of a biomarker panel for assessing cardiovascular risk in diabetic patients with chronic limb-threatening ischemia (chronic limb threatening ischemia (CLTI)): a prospective study
Authors' conclusion
Elevated IL-1, IL-6, CRP, TNF-α, HMGB-1, OPG and Sortilin levels and low Omentin-1 levels at baseline correlate with worse vascular outcomes in diabetic patients with CLTI undergoing LER. Assessment of the inflammatory state with this panel of biomarkers may support physicians to identify a subset of patients more susceptible to the procedure failure and to develop cardiovascular adverse events after LER.
Study context
- Population
- Diabetic patients with CLTI undergoing lower-extremity endovascular revascularization (LER)
- Participants
- 264 patients
- Outcome
- MACE and major adverse limb events (MALE) after LER in relation to baseline biomarker panel (IL-1, IL-6, C-Reactive Protein (CRP), TNF-α, HMGB-1, Osteoprotegerin (OPG), Sortilin, Omentin-1)
- Follow-up
- 1, 3, 6 and 12 months
Methodological detailsnon-randomized
- Non-randomized
Main finding
As reported in the abstract
follow-up
Major adverse cardiac events (MACE) cases
42
Major adverse limb events (MALE) cases
81
Observational data: associations, not effects.
Original publication
Development of a biomarker panel for assessing cardiovascular risk in diabetic patients with chronic limb-threatening ischemia (CLTI): a prospective study. Cardiovasc Diabetol. Published 12 June 2023. doi:10.
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