Magnetic resonance study of visceral, subcutaneous, liver and pancreas fat changes after 12 weeks intermittent fasting in obese participants with prediabetes
Authors' conclusion
Overall weight loss was correlated with fat loss from subcutaneous depots. Losses from different fat depots did not correlate with changes in HbA1c or differ by probiotic supplementation, ethnicity or sex.
Study context
- Population
- Obese participants with prediabetes on 5:2 intermittent fastingMRI at baseline and 12 weeks
- Participants
- 24 participants
- Comparison
- Daily probiotic vs placebo during 5:2 intermittent fasting
Methodological detailsmagnetic resonance imaging study, placebo-controlled, randomized 1:1
- Magnetic resonance imaging study
- Placebo-controlled
- Randomized 1:1
Primary result
As reported in the abstract
Subcutaneous fat (%) changed from baseline to 12 weeks (p < 0.001)
35.9 ± 3.1 to 34.4 ± 3.2
Visceral fat (%) changed from baseline to 12 weeks (p < 0.001)
15.8 ± 1.3 to 14.8 ± 1.2
Liver fat (%) changed from baseline to 12 weeks (p < 0.001)
8.7 ± 0.8 to 7.5 ± 0.7
Pancreatic fat (%) changed from baseline to 12 weeks (p < 0.001)
7.7 ± 0.5 to 6.5 ± 0.5
Further findings
Changes in weight, HbA1c, SAT, VAT, LF and PF, probiotic vs placebo · 12 weeks
- Changes did not differ significantly between probiotic and placebo
Original publication
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