Birthweight is associated with clinical characteristics in people with recently diagnosed type 2 diabetes
Authors' conclusion
Despite younger age at diagnosis, and fewer individuals with obesity and family history of type 2 diabetes, a birthweight <3000 g was associated with more comorbidities, including a higher systolic BP, as well as with greater use of glucose-lowering and antihypertensive medications, in individuals with recently diagnosed type 2 diabetes.
Study context
- Population
- Individuals with recently diagnosed T2D with traced midwife records, Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort
- Participants
- 6,866 individuals
- Exposure
- Birthweight <3000 g and >3700 g vs 3000-3700 g
- Outcome
- Clinical characteristics at T2D onset
Methodological detailscohort-based (DD2 cohort)
- Cohort-based (DD2 cohort)
Main finding
As reported in the abstract
- <3000 g
- PR for Charlson Comorbidity Index Score ≥3 1.36 (95% CI 1.07–1.73)
- <3000 g
- PR for systolic BP ≥155 mmHg 1.26 (95% CI 0.99–1.59)
- <3000 g
- PR for use of ≥3 glucose-lowering drugs 1.33 (95% CI 1.06–1.65)
- <3000 g
- PR for use of ≥3 antihypertensive drugs 1.09 (95% CI 0.99–1.20)
- Per 1000 g decrease in birthweight: younger age of diabetes onset
- 3.3 year (95% CI 2.9, 3.8)
- Per 1000 g decrease in birthweight: lower BMI
- 1.5 kg/m² (95% CI 1.2, 1.7)
- Per 1000 g decrease in birthweight: smaller waist circumference
- 3.9 cm (95% CI 3.3, 4.5)
Observational data: associations, not effects.
Further findings
Clinically defined low birthweight (<2500 g)
- Stronger associations
Higher birthweight
- Most associations appeared linear; higher birthweight associated with characteristics mirroring lower birthweight in opposite directions
Adjustment for polygenic scores for T2D and birthweight
- Results robust to adjustment
Original publication
Birthweight is associated with clinical characteristics in people with recently diagnosed type 2 diabetes. Diabetologia. Published 12 June 2023. doi:10.
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