Low birthweight in patients with type 2 diabetes is associated with elevated risk of cardiovascular events and mortality
Authors' conclusion
Having a birthweight <3000 g is associated with higher CVD risk among patients with type 2 diabetes, driven primarily by risk of stroke and CVD death.
Study context
- Population
- Patients recently diagnosed with T2D with original midwife records, Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohortmedian follow-up 8.5 years
- Participants
- 8,417 participants
- Exposure
- Birthweight <3000 g vs 3000-3700 g
- Outcome
- Composite CVD endpoint:
- MI
- Coronary revascularisation
- Peripheral arterial disease
- Stroke
- Unstable angina
- HF
- CVD death
- Follow-up
- 10 years
Methodological detailsAalen-Johansen estimator with non-CVD death as competing risk, Cox regression adjusted for sex, age, calendar year at birth, family history of diabetes and born-at-term status
- Aalen-Johansen estimator with non-CVD death as competing risk
- Cox regression adjusted for sex, age, calendar year at birth, family history of diabetes and born-at-term status
Main finding
As reported in the abstract
10-year standardised composite CVD risk
Each group vs 3000-3700 gRisk difference (95% CI)
<3000 g
2.9%(0.4–5.4)
Each group vs 3000-3700 gAdjusted hazard ratio (95% CI)
<3000 g
1.20(1.03–1.40)
- Composite CVD endpoints during follow-up
- 1187
Observational data: associations, not effects.
Further findings
| Outcome | RD (95% CI) | |
|---|---|---|
| 10-year MACE risk · 10 years<3000 gvs 3000-3700 g | 2.4% (0.1–4.7) | |
| −20246Difference (linear scale) |
| Outcome | HR (95% CI) | |
|---|---|---|
| 10-year MACE risk · 10 years<3000 gvs 3000-3700 g | 1.22 (1.01–1.46) | |
| 0.512Hazard ratio (log scale) |
- 10-year major adverse cardiovascular events (MACE) risk — MACE during follow-up
- 931
CVD risk components
- Elevated CVD risk primarily driven by stroke, peripheral arterial disease and CVD death
All-cause mortality
- Deaths during follow-up
- 1094
- All-cause mortality showed no substantial difference
Original publication
Low birthweight in patients with type 2 diabetes is associated with elevated risk of cardiovascular events and mortality. Diabetologia. Published 22 May 2024. doi:10.
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