Association Between Visit-to-Visit Glucose Variability and Brain Morphology and Cognitive Function in Type 2 Diabetes
Authors' conclusion
Our findings indicate that higher visit-to-visit GV is associated with reduced cortical thickness, total gray matter volume atrophy, and poorer cognitive performance in patients with T2DM, and these associations are independent of mean HbA1c levels.
Study context
- Population
- Patients with T2D and healthy controls who underwent cognitive assessment and structural MRI
- Participants
- 426 patients
- Exposure
- Levels of visit-to-visit glucose variability in T2D
- T2DMn = 173
- Healthy controlsn = 253reference
- Outcome
- Associations of visit-to-visit GV with brain morphometry and cognitive function in T2D
Main finding
As reported in the abstract
- Higher glucose variability (GV) associated with poorer global cognitive performance and executive function
- After full multivariate adjustment, higher GV linked to cortical thinning in left superior parietal cortex, right postcentral gyrus and insula, and reduced total gray matter volume
- No association between GV and cortical volume or surface area
- Adjusted for mean HbA1c and other traditional risk factors
Observational data: associations, not effects.
Original publication
Association Between Visit-to-Visit Glucose Variability and Brain Morphology and Cognitive Function in Type 2 Diabetes. J Clin Endocrinol Metab. Published 8 April 2025. doi:10.
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