Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes
Authors' conclusion
This study suggests that the microbiome-metabolome axis is a modifiable target for T2D management, with optimal health benefits achievable through a combination of lifestyle modifications.
Study context
- Population
- Two Swedish cohorts; impaired glucose control (prediabetes and T2D)
- Participants
- 1,167 cohorts2 Swedish cohorts
- Outcome
- Blood metabolites associated with impaired glucose control
Methodological detailstwo Swedish cohorts
- Two Swedish cohorts
Main finding
As reported in the abstract
- Blood metabolites associated with impaired glucose control
- over 500
- Share linked to an altered gut microbiome
- approximately one-third
Observational data: associations, not effects.
Further findings
Short-term lifestyle changes (e.g. diet, exercise)
- Modulated microbiome-associated metabolites in a lifestyle-specific manner
Original publication
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes. Nat Med. Published 8 April 2025. doi:10.
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