Differential physical activity responses to diabetes risk reduction interventions according to prediabetes phenotype in at-risk individuals: pooled analysis from three randomised controlled trials
Authors' conclusion
The effectiveness of structured, group-based interventions with goal setting to promote physical activity differs by glycaemic status; those with IFG were least responsive.
Study context
- Population
- Individuals at risk of T2D, stratified by normoglycaemia, impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or IFG+IGT; mean age 63–65 years
- Participants
- 2,150 individuals3 RCTs
- Comparison
- Structured group-based lifestyle intervention vs usual care, by prediabetes phenotype
- Outcome
- Change in physical activity (steps/day), stratified by IFG and/or IGT
Methodological detailssubgroup analysis by prediabetes phenotype, up to 48 months annual follow-up
- Subgroup analysis by prediabetes phenotype
- Up to 48 months annual follow-up
Pooled result
As reported in the abstract
Steps/day, intervention vs usual care, by phenotype
Intervention vs Usual careMean difference, steps/day (95% CI)
Normoglycaemia
247(4–491)
IGT
523(229–818)
IFG+IGT
808(402–1213)
IFG; no increase
71(−429 to 571)
Further pooled results
Baseline steps/day by phenotype
| Outcome | Mean (mmol/l) (95% CI) |
|---|---|
| 2 h post-challenge glucose, IFG+IGT subgroupIFG+IGT | −0.5 (−0.9 to 0.0) |
2 h post-challenge glucose, IFG+IGT subgroup
- Intervention improved 2 h glucose in the IFG+IGT group only
Original publication
Differential physical activity responses to diabetes risk reduction interventions according to prediabetes phenotype in at-risk individuals: pooled analysis from three randomised controlled trials. Diabetologia. Published 14 September 2026. doi:10.
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