Differential effect of nonpharmacological interventions according to prediabetes phenotype: Systematic review and meta‐analysis of randomized clinical trials
Authors' conclusion
Diverse lifestyle modification interventions improved glucose levels in people with IFG, but not in those with IGT. Our findings imply that different non-pharmacological interventions are warranted for IGT and IFG.
Study context
- Population
- Individuals with IGT or impaired fasting glucose (IFG) enrolled in randomized controlled trials (RCTs) of nonpharmacological (lifestyle modification) interventions36 RCTs
- Comparison
- Effect of lifestyle modification by prediabetes phenotype: IGT vs IFG
- Outcome
- Effect of lifestyle modification on glucose level
Pooled result
As reported in the abstract
MD, mg/dL (95% CI)
IFGlifestyle modification effect in IFG; significant
−1.56(−2.71 to −0.40)
IGTlifestyle modification effect in IGT; not significant
1.47(−1.33 to 4.28)
Further pooled results
Progression from impaired glycaemia to T2D
Reversion to normoglycaemia
Original publication
Differential effect of nonpharmacological interventions according to prediabetes phenotype: Systematic review and meta‐analysis of randomized clinical trials. Diabet Med. Published 15 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →