Neurovascular decoupling of frontoparietal cortex-putamen-cerebellum network in type 2 diabetes patient: Potential biomarker for abnormal eating patterns
Authors' conclusion
The frontoparietal cortex-putamen-cerebellum network was the suspicious T2DM-related abnormal eating pattern network. Neurovascular decoupling of the network, especially that of Putamen_R, occurred early and might serve as a biomarker for abnormal eating patterns in T2DM patients.
Study context
- Population
- T2DM patients and matched healthy controls undergoing resting state functional MRI
- Participants
- 41 vs 43
- Exposure
- T2DM vs healthy controls
- T2DMn = 41
- Healthy controls (HC)n = 43reference
- Outcome
- Effective connectivity of frontoparietal cortex-putamen-cerebellum network
Methodological detailsmatched healthy controls, resting state functional MRI
- Matched healthy controls
- Resting state functional MRI
Main finding
As reported in the abstract
- T2DM vs HC: P = 0.023
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Fractional windows of the densest stateHigher in T2DM | P = 0.009 |
| Mean dwell time of the densest stateHigher in T2DM | P = 0.009 |
Eating behaviour
- Increased uncontrolled eating, internal and external loci of hunger in T2DM
Neurovascular decoupling and eating behaviour
- Neurovascular decoupling of the network correlated with T2DM-specific eating behaviour characteristics
- Neurovascular decoupling coefficient of Putamen_R changed at the very beginning of T2DM
Original publication
Neurovascular decoupling of frontoparietal cortex-putamen-cerebellum network in type 2 diabetes patient: Potential biomarker for abnormal eating patterns. Diabetes Res Clin Pract. Published 13 April 2025. doi:10.
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