Phthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN)
Authors' conclusion
Some phthalate metabolites were associated with a higher incidence of diabetes over 6 years, but the associations were inconsistent across racial/ethnic groups. Whether phthalates cause diabetes requires further investigation.
Study context
- Population
- Racially/ethnically diverse midlife women without diabetes in 1999–2000, Study of Women's Health Across the Nation (SWAN) Multipollutant Study
- Participants
- 1,308 women
- Exposure
- Per doubling of urinary phthalate metabolite concentrations
- Outcome
- Incident diabetes
- Follow-up
- 6 years
Methodological detailsmultipollutant study, time-varying exposure, Cox proportional hazards models, Eleven phthalate metabolites measured in spot urine in 1999-2000 and 2002-2003
- Multipollutant study
- Time-varying exposure
- Cox proportional hazards models
- Eleven phthalate metabolites measured in spot urine in 1999-2000 and 2002-2003
Main finding
As reported in the abstract
Cumulative incidence of diabetes (61 women)
4.7%
White women: HR per doubling of mono-carboxyisononyl phthalate (MCNP)
1.30
95% CI 1.03–1.65
White women: HR per doubling of mono-isobutyl phthalate (MiBP)
1.63
95% CI 1.18–2.25
White women: each doubling of MiBP, monobenzyl, mono-carboxyoctyl, MCNP and mono(3-carboxypropyl) phthalate associated with higher diabetes incidence
30% to 63%
Observational data: associations, not effects.
Original publication
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