Lipids & metabolic liver disease
Phthalates exposure, biological aging, and increased risks of insulin resistance, prediabetes, and diabetes in adults with metabolic dysfunction-associated steatotic liver disease
Authors' conclusion
Phthalates exposure of MASLD adults was related to increased risks of IR, prediabetes, and diabetes, which were interactively aggravated by biological aging. Controlling phthalates exposure and biological aging probably hold significant relevance for the prevention of diabetes in the MASLD population.
Study context
- Population
- US adults with MASLD
- Participants
- 3,045 adults
- Exposure
- Urinary phthalate metabolites and biological aging vs insulin resistance (IR), prediabetes and diabetes
- Outcome
- Prevalent IR, prediabetes and diabetes
Methodological detailssurvey-weighted logistic regression, weighted quantile sum (WQS) regression
- Survey-weighted logistic regression
- Weighted quantile sum (WQS) regression
Main finding
As reported in the abstract
Individual and mixed effects of phthalates on IR, prediabetes and diabetes
- Mono-2-ethyl-5-carboxypentyl phthalate with IR, OR
- 1.147 [1.041;1.264] (95% CI)
- Mono-(2-ethyl-5-hydroxyhexyl) phthalate with IR, OR
- 1.175 [1.073;1.288] (95% CI)
- Mono-(2-ethyl-5-oxohexyl) phthalate with IR, OR
- 1.140 [1.040;1.250] (95% CI)
- Mono-isobutyl phthalate with prediabetes, OR
- 1.216 [1.064;1.390] (95% CI)
- WQS phthalate mixture with IR, OR
- 1.166 [1.034;1.315] (95% CI)
- WQS phthalate mixture with prediabetes, OR
- 1.194 [1.006;1.416] (95% CI)
- WQS phthalate mixture with diabetes, OR
- 1.214 [1.026;1.437] (95% CI)
Observational data: associations, not effects.
Further findings
Biological aging and interaction with phthalates: high vs low phthalate mixture and phenotypic age (PA)
- IR, OR
- 2.468 [1.474;4.133] (Pinteraction = 0.031) (95% CI)
- Prediabetes, OR
- 1.975 [1.189;3.278] (Pinteraction = 0.009) (95% CI)
- Diabetes, OR
- 6.065 [3.210;11.460] (Pinteraction = 0.013) (95% CI)
- Biological age (BA) and PA positively associated with IR, prediabetes and diabetes and significantly interacted with phthalates
Original publication
Phthalates exposure, biological aging, and increased risks of insulin resistance, prediabetes, and diabetes in adults with metabolic dysfunction-associated steatotic liver disease. Diabetes Metab. Published 10 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →