Lipids & metabolic liver disease
Reliable Monitoring of Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease Using Imaging: A Systematic Literature Review and Meta-Analysis on Measurement Repeatability
Authors' conclusion
This systematic review and meta-analysis showed that cT1 and LFC are more reliable in detecting change in liver health in people living with MASLD-metabolic dysfunction-associated steatohepatitis, compared to liver stiffness. Liver stiffness measurements are less suited to monitoring individual patients.
Study context
- Population
- Studies in MASLD examining repeatability of noninvasive imaging (PubMed Central and MEDLINE, 2015–2025); mean age 45 years, 43% female
- Participants
- 1,040 participants19 studies
- Comparison
- Repeatability of MR-derived cT1, liver fat content (LFC) and magnetic resonance elastography (MRE) vs US-based VCTE LSM, controlled attenuation parameter and shear wave elastography
- Outcome
- Relative repeatability coefficient for same-day (%RC) or different-day (%RCDD) repeat tests
Methodological detailsrandom-effects meta-analysis
- Random-effects meta-analysis
Pooled result
As reported in the abstract
Pooled random-effects average %RCDD · median interval of 14 days between repeat scans
Further pooled results
Same-day repeatability
- Relative repeated measures on the same day values were consistently lower across all tests
Original publication
Reliable Monitoring of Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease Using Imaging: A Systematic Literature Review and Meta-Analysis on Measurement Repeatability. Endocr Pract. Published 1 October 2025. doi:10.
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