Lipids & metabolic liver disease
Effect of changes in the triglyceride-glucose index on atherogenic lipid profiles in coronary artery disease patients receiving lipid-lowering therapy: a prospective cohort study
Authors' conclusion
Higher TyG levels were positively associated with atherogenic lipid profiles and failure to achieve lipid goals. In addition, upward changes in TyG over time were related to worsened atherogenic lipid status, particularly among patients receiving low-/moderate-intensity LLT. These findings support the routine monitoring of TyG to identify patients at risk of poor lipid control who may require high-intensity LLT.
Study context
- Population
- Patients with coronary artery disease (CAD) receiving lipid-lowering therapy (LLT), followed over a median of one year
- Participants
- 1,393 patients
- Exposure
- Baseline levels and changes in triglyceride-glucose (TyG) index vs atherogenic lipid parameters
- Outcome
- Association of baseline TyG with failure to achieve lipid targets
- Follow-up
- follow-up
Main finding
As reported in the abstract
Higher baseline TyG and failure to achieve Non-HDL-C target, OR
1.23 (1.01-1.51) (95% CI)
Higher baseline TyG and failure to achieve remnant cholesterol (RC) target, OR
1.38 (1.09-1.76) (95% CI)
Observational data: associations, not effects.
Further findings
Percent increase in lipids per 1% increase in TyG index
- LDL-C, β
- 1.10
- Non-HDL-C, β
- 1.81
- RC, β
- 4.92
- P (all)
- P < 0.001
TyG tertile transitions
- Lowest to highest TyG tertile: significant lipid worsening; highest to lowest: reductions in RC and Non-HDL-C
LLT intensity
- High-intensity LLT led to greater reductions in TyG and lipid levels, mitigating the adverse lipid effects of TyG elevation
Subgroups
- Adverse effects more evident in women and in those with obesity or prior revascularization
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →