Lipids & metabolic liver disease
The triglyceride-glucose index predicts 1-year major adverse cardiovascular events in end-stage renal disease patients with coronary artery disease
Main finding · MACEResult — go to the resultHazard ratio 1.63 95% CI 1.14–2.35Authors' conclusion
The TyG index might serve as a valuable and dependable indicator of MACE risk in individuals with dialysis and CAD, indicating its potential significance in enhancing risk categorization in clinical settings.
Study context
- Population
- Patients on dialysis (end-stage renal disease (ESRD)) with coronary artery disease (CAD), multiple centres in China, January 2015 to June 2021
- Participants
- 959 patients
- Exposure
- Triglyceride-glucose (TyG) index tertiles
- Outcome
- MACE: composite of death from any cause, non-fatal MI and non-fatal stroke
- Follow-up
- 1 year
Main finding
MACE
Hazard ratio
1.63
95% CI 1.14–2.35
P = 0.007
By group
Tertile 3vs Tertile 1
HR 1.63 (95% CI 1.14–2.35); P = 0.007
As reported in the abstract
Observational data: associations, not effects.
Further findings
Major adverse cardiovascular events (MACE) per unit increase in TyG index
- HR per unit increase in TyG index
- 1.37 (95% CI 1.13-1.66, P = 0.001)
Restricted cubic spline analysis
- Connection between TyG index and MACE (P for nonlinearity > 0.05)
Incremental prediction
- Adding TyG index to GRACE risk score or fully adjusted baseline model considerably enhanced MACE prediction (C-statistic, continuous net reclassification improvement (NRI), integrated discrimination improvement (IDI))
Original publication
The triglyceride-glucose index predicts 1-year major adverse cardiovascular events in end-stage renal disease patients with coronary artery disease. Cardiovasc Diabetol. Published 27 October 2023. doi:10.
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