Lipids & metabolic liver disease
High Lipoprotein(a) May Explain One-Quarter of Clinical Familial Hypercholesterolemia Diagnoses in Danish Lipid Clinics
Authors' conclusion
Elevated lipoprotein(a) was common in individuals referred to Danish lipid clinics and in one-quarter of individuals who fulfilled a clinical diagnosis of FH, this was partly due to elevated lipoprotein(a). These findings support the notion that the LPA gene should be considered an important causative gene in patients with clinical FH and further support the importance of measuring lipoprotein(a) when diagnosing FH as well as for stratification of cardiovascular risk.
Study context
- Population
- Individuals referred to 15 Danish lipid clinics with suspected familial hypercholesterolemia (FH) according to nationwide referral criteria, recruited September 1, 2020 to November 30, 2021206 with clinical FH
- Participants
- 1,166 individuals
- Outcome
- Fraction of individuals fulfilling a clinical diagnosis of FH (Dutch Lipid Clinical Network criteria) partly due to elevated lipoprotein(a), after adjusting low-density lipoprotein cholesterol (LDL-C) for 30% cholesterol content in lipoprotein(a)
Methodological detailsmulticentre, 15 Danish lipid clinics
- Multicentre
- 15 Danish lipid clinics
Main finding
As reported in the abstract
Clinical FH diagnosis partly due to high lipoprotein(a)
27%
55/206
Observational data: associations, not effects.
Further findings
Lipoprotein(a) in referred individuals
- Median lipoprotein(a)
- 15 mg/dL (29 nmol/L)
- Lipoprotein(a) ≥50 mg/dL (105 nmol/L)
- 28%
- Lipoprotein(a) ≥180 mg/dL (389 nmol/L)
- 2%
Original publication
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