Lipids & metabolic liver disease
Unravelling the liver-brain connection: A two-sample Mendelian randomization study investigating the causal relationship between non-alcoholic fatty liver disease (NAFLD) and cortical structure
Main finding · Cortical thickness, pars orbitalis gyrusResult — go to the resultβ −0.008 mm 95% CI −0.013 mm to −0.004Authors' conclusion
The two-sample MR study supports the existence of a liver-brain axis by demonstrating a causal association between NAFLD and changes in cortical structures. These findings emphasize the potential association between NAFLD and brain health, which could have implications for preventing and treating cognitive deficits and neuropsychiatric conditions in patients with NAFLD.
Study context
- Population
- Genome-wide association studies (GWAS) summary data for NAFLD from large-scale cohorts; cortical surface area (SA) and thickness (TH) from ENIGMA Consortium magnetic resonance imaging (MRI) dataENIGMA MRI data
- Participants
- 33,992 participants
- Comparison
- Genetically predicted NAFLD vs cortical structure
- Outcome
- Causal effect of NAFLD on cortical surface area and cortical thickness (inverse-variance weighted (IVW))
Methodological detailsinverse-variance weighted primary method, sensitivity analyses: MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO), MR-Egger, weighted median
- Inverse-variance weighted primary method
- Sensitivity analyses: MR-PRESSO, MR-Egger, weighted median
Main finding
Cortical thickness, pars orbitalis gyrus
β
−0.008 mm
95% CI −0.013 mm to −0.004
P = 3.00 × 10-4
As reported in the abstract
Further findings
Sensitivity analyses
- No significant heterogeneity and pleiotropy were identified
Original publication
Unravelling the liver-brain connection: A two-sample Mendelian randomization study investigating the causal relationship between NAFLD and cortical structure. Diabetes Res Clin Pract. Published 29 September 2023. doi:10.
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