Lipids & metabolic liver disease
Cumulative exposure to high remnant-cholesterol concentrations increases the risk of cardiovascular disease in patients with hypertension: a prospective cohort study
Authors' conclusion
A consistently high remnant-cholesterol concentration increases the risk of CVD in individuals with hypertension. Therefore, the achievement of blood pressure and RC concentration targets should help reduce the risk of CVD in individuals with hypertension.
Study context
- Population
- Individuals without cardiovascular disease (CVD) with three consecutive total cholesterol, high-density lipoprotein-cholesterol (HDL-C) and TG measurements, 2006–2010 (14,349 with hypertension, 14,349 without)14,349 with hypertension
- Participants
- 28,698 individuals
- Exposure
- Cumulative remnant-cholesterol (Cum-RC) quartiles Q2–Q4 vs Q1 in patients with hypertension
- Outcome
- CVD
- Follow-up
- Median 10.9 (IQR 10.5-11.3) years
Main finding
As reported in the abstract
median 10.9 years
Each group vs Q1Adjusted hazard ratio (CI)P value
Q2
1.07(0.92,1.26)
Q3
1.08(0.91,1.28)
Q4
1.26(1.03,1.54)
P = 0.0405- Participants with hypertension who developed CVD
- 1,444
Observational data: associations, not effects.
Further findings
| Outcome | aHR (CI) | P value | |
|---|---|---|---|
| MIQ2vs Q1 | 1.51 (1.00,2.31) | ||
| MIQ3vs Q1 | 2.02 (1.22,3.27) | ||
| MIQ4vs Q1 | 2.08 (1.41,3.28) | P < 0.0001 | |
| Ischemic strokeQ2vs Q1 | 1.02 (0.84,1.24) | ||
| Ischemic strokeQ3vs Q1 | 1.04 (0.86,1.25) | ||
| Ischemic strokeQ4vs Q1 | 1.29 (1.02,1.62) | P = 0.0336 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Hemorrhage stroke
- No significant relationship between Cum-RC and risk of hemorrhage stroke
Hypertension vs no hypertension at same Cum-RC
- At the same Cum-RC, CVD risk significantly higher with hypertension than without
Original publication
Cumulative exposure to high remnant-cholesterol concentrations increases the risk of cardiovascular disease in patients with hypertension: a prospective cohort study. Cardiovasc Diabetol. Published 21 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →