Lipids & metabolic liver disease
Metabolic syndrome‐related cognitive impairment with white matter hyperintensities and functional network analysis
Authors' conclusion
WMHs mediated the association between MetS and cognitive function, with a decline in the efficiency of functional brain networks being a probable neural mechanism.
Study context
- Population
- Participants with metabolic syndrome (MetS) with or without white matter hyperintensities (WMHs), and controls
- Participants
- 50 / 45 / 50
- Exposure
- MetS with WMHs vs MetS without WMHs vs controls
- MetS and WMHs (MetS-WMHs)n = 50
- MetS without WMHsn = 45
- Controln = 50reference
- Outcome
- Functional network efficiency and mediation of MetS-related cognitive impairment by WMHs
Methodological detailsresting-state functional MRI, graph theory analysis, mediation analysis
- Resting-state functional MRI
- Graph theory analysis
- Mediation analysis
Main finding
As reported in the abstract
- MetS-WMHs vs controls: lower global, local and nodal efficiency, mainly in salience network regions
- Significant correlation between functional network efficiency and cognitive performance
- WMHs mediated MetS and cognitive decline, affecting attention/executive function, language and global cognitive function
Observational data: associations, not effects.
Original publication
Metabolic syndrome‐related cognitive impairment with white matter hyperintensities and functional network analysis. Obesity (Silver Spring). Published 19 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →