Lipids & metabolic liver disease
Cardiac Insulin Resistance in Subjects With Metabolic Syndrome Traits and Early Subclinical Atherosclerosis
Authors' conclusion
Apparently healthy individuals without cardiac 18F-FDG uptake have higher HOMA-IR and higher prevalence of MetS traits, cardiovascular risk factors, and early atherosclerosis. An improvement in cardiometabolic profile is associated with the recovery of myocardial 18F-FDG uptake at follow-up.
Study context
- Population
- Asymptomatic individuals from the Progression of Early Subclinical Atherosclerosis (PESA) study; 50.6 [46.9–53.6] years, 83.7% male
- Participants
- 821 individuals
- Exposure
- No myocardial 18F-FDG uptake vs positive uptake
- No myocardial uptaken = 156
- Outcome
- Prevalence of MetS
- Follow-up
- Baseline
Methodological detailstwo whole-body 18F-FDG PET-MR 4.8 ± 0.6 years apart
- Two whole-body 18F-FDG PET-MR 4.8 ± 0.6 years apart
Main finding
As reported in the abstract
- No myocardial uptake vs Positive uptake: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Hypertension · baselineHigher with no myocardial uptake (29.0% vs. 18.0%) | P = 0.002 |
| Diabetes · baselineHigher with no myocardial uptake (11.0% vs. 3.2%) | P < 0.001 |
| HOMA-IR · baselineHigher with no myocardial uptake (1.64% vs. 1.23%) | P < 0.001 |
| Early atherosclerosis (arterial 18F-FDG uptake) · baselineHigher prevalence with no myocardial uptake | P = 0.004 |
Follow-up changes
- Increase in HOMA-IR associated with progressive decrease in myocardial uptake
- P < 0.001
- Unchanged presence/absence categorization
- 82%
- Metabolic syndrome (MetS) regression associated with increase in myocardial uptake
- P < 0.001
- Associations replicated; MetS more frequent without myocardial uptake
Original publication
Cardiac Insulin Resistance in Subjects With Metabolic Syndrome Traits and Early Subclinical Atherosclerosis. Diabetes Care. Published 15 September 2023. doi:10.
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