Lipids & metabolic liver disease
Triglyceride to High-Density Lipoprotein Cholesterol Ratio as a Marker of Subclinical Coronary Atherosclerosis and Hepatic Steatosis in Familial Hypercholesterolemia
Authors' conclusion
TG/HDL-C ratio was strongly associated with HRP, HS, and cardiac events in patients with FH treated with long-term cholesterol-lowering therapy.
Study context
- Population
- Asymptomatic patients with familial hypercholesterolemia (FH) who underwent CT coronary angiography for cardiovascular risk assessment; mean age 49 years, 44% male
- Participants
- 290 patients
- Exposure
- TG/HDL-C ratio and HRP and hepatic steatosis (HS)
- Outcome
- Association of TG/HDL-C ratio with high-risk coronary artery plaque (HRP) and hepatic steatosis (HS)
Main finding
As reported in the abstract
HRP: OR per TG/HDL-C ratio
1.27
95% CI 1.04–1.56P = .020
HS: OR per TG/HDL-C ratio
1.71
95% CI 1.17–2.51P = .005
Observational data: associations, not effects.
Further findings
TG/HDL-C ratio and HRP in patients on lipid-lowering medications
- TG/HDL-C ratio associated with HRP (P = .042)
Prediction of HRP: model including TG/HDL-C ratio vs FH-Risk-Score
- AUC 0.74 vs 0.63; P = .004
MI or coronary revascularization · median follow-up 91 months
- Cardiac events recorded
- 10
- Elevated TG/HDL-C ratio predicted MI or coronary revascularization (P = .043)
Correlation of TG/HDL-C ratio with markers of cardiometabolic dysfunction
- Lipid accumulation product (P < .001)
- r = 0.81
- Visceral adiposity index (P < .001)
- r = 0.96
- Triglyceride-glucose index (P < .001)
- r = 0.91
Original publication
Triglyceride to High-Density Lipoprotein Cholesterol Ratio as a Marker of Subclinical Coronary Atherosclerosis and Hepatic Steatosis in Familial Hypercholesterolemia. Endocr Pract. Published 26 February 2025. doi:10.
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