Lipids & metabolic liver disease
The triglyceride glucose: high-density lipoprotein cholesterol ratio is associated with coronary artery calcification evaluated via non-gated chest computed tomography (CT)
Authors' conclusion
An increase in the TYG/HDL-c ratio is significantly positively associated with the risk of CAC, and the TYG/HDL-c ratio has a more stable association with CAC than TYG.
Study context
- Population
- Participants who underwent CT screening for lung cancer, 2018–2020; mean age 51.8 ± 15.5 years, 61.2% men
- Participants
- 9,585 participants
- Exposure
- Triglyceride glucose (TYG)/high-density lipoprotein cholesterol (HDL-c) ratio and TYG index vs coronary artery calcification (CAC)
- Outcome
- CAC evaluated on non-gated chest CT
Main finding
As reported in the abstract
Association with CAC (multivariate logistic regression)
- CAC detected
- 2515 of 9585
- TYG index, OR
- 1.06 (1.02-1.10) (95% CI)
- TYG/HDL-c ratio, OR
- 1.32 (1.14-1.51) (95% CI)
- TYG index, further adjusted for serum lipids, OR (95% CI); no association
- 1.23 (0.99-1.54)
- TYG/HDL-c ratio, further adjusted for LDL-C and total cholesterol, OR
- 1.21 (1.09-1.35) (95% CI)
Observational data: associations, not effects.
Further findings
CAC prevalence by TYG/HDL-c ratio quartile
P < 0.001
Single-vessel and multivessel calcification, TYG/HDL-c ratio
- Single vessel, OR
- 1.14 (1.05-1.23) (95% CI)
- Multivessel, OR
- 1.15 (1.05-1.21) (95% CI)
Subgroups and dose-response
- Similar trends by TYG index and TYG/HDL-c quartiles and in subjects older than 60 years
- TYG/HDL ratio had a better dose-responsive relationship than TYG index (restricted cubic splines)
- Association mainly in nondiabetic or nonhypertensive participants, regardless of LDL-C levels
Identification of CAC (ROC), subjects older than 60 years
- AUC, TYG/HDL-c ratio vs TYG index
- 0.54 vs. 0.52, p < 0.01
Original publication
The triglyceride glucose: high-density lipoprotein cholesterol ratio is associated with coronary artery calcification evaluated via non-gated chest CT. Cardiovasc Diabetol. Published 24 October 2024. doi:10.
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