Lipids & metabolic liver disease
Triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio as potential cardiovascular disease risk factors: an analysis of UK biobank data
Authors' conclusion
Elevated baseline TyG index and TG/HDL-C ratio were associated with a higher risk of CVD after adjustment for the well-established CVD risk factors. These associations were largely mediated by greater prevalence of dyslipidemia, type 2 diabetes, and hypertension.
Study context
- Population
- UK Biobank participants with triglyceride-glucose (TyG) index and TG/HDL-C ratio data, free from cardiovascular disease (CVD) at baseline
- Participants
- 403,335 participants
- Exposure
- Higher quartiles vs lowest quartile of TyG index and TG/HDL-C ratio
- Outcome
- Incident total CVD
- Follow-up
- Median 8.1 years
Methodological detailsUK Biobank, multivariable-adjusted Cox models, mediation analyses
- UK Biobank
- Multivariable-adjusted Cox models
- Mediation analyses
Main finding
As reported in the abstract
Total CVD
Multivariable-adjusted HR
- TyG Q2 vs TyG Q1
- 1.05
- TyG Q3 vs TyG Q1
- 1.05
- TyG Q4 vs TyG Q1
- 1.19
- TG/HDL-C Q2 vs TG/HDL-C Q1
- 1.07
- TG/HDL-C Q3 vs TG/HDL-C Q1
- 1.13
- TG/HDL-C Q4 vs TG/HDL-C Q1
- 1.29
- Incident CVD overall
- 19,754 (4.9%)
Observational data: associations, not effects.
Further findings
CHD and stroke cases · median follow-up 8.1 years
- CHD
- 16,404 (4.1%)
- Stroke
- 3976 (1.0%)
Mediation of TyG index–CVD association
- Dyslipidemia
- 45.8%
- T2D
- 27.0%
- Hypertension
- 15.0%
Mediation of TG/HDL-C ratio–CVD association
- Dyslipidemia
- 40.0%
- T2D
- 11.8%
- Hypertension
- 13.3%
Original publication
Triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio as potential cardiovascular disease risk factors: an analysis of UK biobank data. Cardiovasc Diabetol. Published 16 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →