Lipids & metabolic liver disease
Postprandial triglycerides and fibroblast growth factor 19 as potential screening tools for paediatric non‐alcoholic fatty liver disease
Authors' conclusion
The postprandial TG response is increased in adolescents with obesity with hepatic steatosis, with or without NAFLD. Our preliminary analysis demonstrates 4 h TG differentiate patients with NAFLD from those without, supporting a role for the AFTT as a screening tool for paediatric NAFLD.
Study context
- Population
- Adolescents with NAFLD, obesity or normal weight completing an abbreviated fat tolerance test (AFTT) with a high-fat meal after an overnight fast
- Participants
- 9 / 13 / 15
- Comparison
- Adolescents with NAFLD vs controls with obesity and with normal weight
- NAFLDn = 9
- Obesity (OB)n = 13
- Normal weight (NW)n = 15reference
- Outcome
- Postprandial TG and fibroblast growth factor 19 (FGF19) response to AFTT differentiating NAFLD
- Follow-up
- 4 h post-meal
Methodological detailsLiver steatosis and fibrosis measured via Fibroscan
- Liver steatosis and fibrosis measured via Fibroscan
Performance
As reported in the abstract
4 h TG
NAFLD vs NW: P < 0.05 · OB vs NW: P < 0.05
- 4 h triglyceride (TG) area under the receiver operating curve (AUROC) for NAFLD (only biochemical outcome with diagnostic accuracy)
- 0.77 (95% CI 0.60-0.94; p = 0.02)
Further findings
4 h TG by steatosis (entire cohort) · 4 h post-meal
- 4 h TG greater with high vs low steatosis
- 98%
4 h FGF19 by steatosis · 4 h post-meal
- 4 h FGF19, but not fasting FGF19, higher with low vs high steatosis
- P < 0.05
Original publication
Postprandial triglycerides and fibroblast growth factor 19 as potential screening tools for paediatric non‐alcoholic fatty liver disease. Pediatr Obes. Published 3 February 2023. doi:10.
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