Thyroid Function and Non-alcoholic Fatty Liver Disease in Children and Adolescent With Obesity: A Systematic Review and Meta-Analysis
Pooled result · TSHResult — go to the resultMean difference 0.37 mIU/L 95% CI 0.07–0.66Authors' conclusion
In pediatric obesity, NAFLD is associated with higher TSH levels in the absence of significant changes in circulating thyroid hormone concentrations.
Study context
- Population
- Children and adolescents with obesity
- Participants
- 5,145 children10 studies
- Comparison
- Non-alcoholic fatty liver disease (NAFLD) vs no NAFLD
- Outcome
- Serum TSH, free thyroxine and free triiodothyronine levels
Methodological detailsrandom-effects meta-analysis
- Random-effects meta-analysis
Pooled result
TSH
Mean difference
0.37 mIU/L
95% CI 0.07–0.66
NAFLDvs Controls without NAFLD
mean difference 0.37 mIU/L (95% CI 0.07–0.66)
As reported in the abstract
Further pooled results
| Outcome | SMD (95% CI) | |
|---|---|---|
| Free thyroxine | −0.35 (−1.15 to 0.45) | |
| Free triiodothyronine | 0.35 (−0.26 to 0.96) | |
| −1.5−1−0.500.51Difference (linear scale) |
Original publication
Thyroid Function and Non-alcoholic Fatty Liver Disease in Children and Adolescent With Obesity: A Systematic Review and Meta-Analysis. Endocr Pract. Published 9 April 2026. doi:10.
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