Lipids & metabolic liver disease
Effect of Indo‐Mediterranean diet versus calorie‐restricted diet in children with non‐alcoholic fatty liver disease: A pilot randomized control trial
Authors' conclusion
Both IMD and CRD can improve the various anthropometric, clinical, imaging and biochemical parameters but IMD was superior to CRD in terms of reducing CAP values and weight/BMI over 180 days in overweight/obese NAFLD children.
Study context
- Population
- Indian overweight children and adolescents aged 8–18 years with biopsy-proven non-alcoholic fatty liver disease (NAFLD)34 completed (18 Indo-Mediterranean diet (IMD), 16 calorie-restricted diet (CRD))
- Participants
- 39 children
- Comparison
- Indo-Mediterranean diet vs calorie-restricted diet
Methodological detailspilot
- Pilot
Primary result
As reported in the abstract
Decrease in controlled attenuation parameter (CAP) (hepatic steatosis, transient elastography) · 180 days
- IMD vs CRD: 95% CI 4.2–73.4; P = 0.042
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Decrease in weight · 180 daysSignificantly higher decrease with IMD | (95% CI 0.75–5.5) | P = 0.046 |
| Decrease in BMI · 180 daysSignificantly higher decrease with IMD | (95% CI 0.21–2.05) | P = 0.014 |
Pediatric NAFLD Fibrosis Index (PNFI) · 180 days
- No significantly higher decrease with IMD vs CRD
Liver stiffness, serum cholesterol, LDL and HOMA-IR · 180 days
- Decreased only in IMD
- P < 0.001
Predictors of delta-CAP
- Delta-weight was the only independent variable associated with delta-CAP
Original publication
Effect of Indo‐Mediterranean diet versus calorie‐restricted diet in children with non‐alcoholic fatty liver disease: A pilot randomized control trial. Pediatr Obes. Published 2 September 2024. doi:10.
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