Impact of non‐alcoholic fatty liver disease and fibrosis on mortality and kidney outcomes in patients with type 2 diabetes and chronic kidney disease: A multi‐cohort longitudinal study
Main finding · Overall mortality (NHANES cohort)Result — go to the resultHazard ratio 1.53 95% CI 1.21–1.95Authors' conclusion
In patients with type 2 diabetes and chronic kidney disease, the NAFLD presence and elevated FIB-4 scores link to heightened mortality risk and ESKD susceptibility. Moreover, NAFLD shows a causal relationship with cardio-cerebrovascular events.
Study context
- Population
- Patients with T2D and CKD: National Health and Nutrition Examination Survey (NHANES) cohort and kidney biopsy cohort, West China Hospital of Sichuan Universitytwo cohorts: 1172 and 326 · NHANES cohort 1,172
- Exposure
- Non-alcoholic fatty liver disease (NAFLD) vs no NAFLD; advanced liver fibrosis
- Outcome
- Overall mortality (NHANES cohort)
Methodological detailstwo longitudinal cohorts, Cox regression
- Two longitudinal cohorts
- Cox regression
Main finding
As reported in the abstract
Hazard ratio
1.53
95% CI 1.21–1.95
NAFLDvs No NAFLD
HR 1.53 (95% CI 1.21–1.95)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Cardio-cerebrovascular disease mortality (NHANES) | 1.63 (1.12–2.37) | |
| Heart disease mortality (NHANES) | 1.58 (1.00–2.49) | |
| Cerebrovascular disease mortality (NHANES) | 3.95 (1.48–10.55) | |
| End-stage kidney disease (kidney biopsy cohort) | 2.17 (1.41–3.34) | |
| 0.050.21520Hazard ratio (log scale) |
Advanced liver fibrosis (FIB-4 >2.67) (NHANES)
- Associated with overall, cardio-cerebrovascular disease and heart disease mortality
End-stage kidney disease (kidney biopsy cohort)
- Elevated FIB-4 or NAFLD Fibrosis Scores predicted future ESKD after full adjustment
Renal histology (kidney biopsy cohort)
- Liver fibrosis positively correlated with renal interstitial fibrosis and tubular atrophy
Mendelian randomization
- Supported a causal relationship between NAFLD and cardio-cerebrovascular events
Original publication
Impact of non‐alcoholic fatty liver disease and fibrosis on mortality and kidney outcomes in patients with type 2 diabetes and chronic kidney disease: A multi‐cohort longitudinal study. Diabetes Obes Metab. Published 18 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →