Association Between Accelerometer-Measured Irregular Sleep Duration and Type 2 Diabetes Risk: A Prospective Cohort Study in the UK Biobank
Authors' conclusion
Irregular sleep duration was associated with higher diabetes risk, particularly in individuals with a lower diabetes PRS and longer sleep duration.
Study context
- Population
- UK Biobank participants free of diabetes when providing accelerometer data in 2013–2015 (mean age 62 years), followed until May 2022
- Participants
- 84,421 participants
- Exposure
- Categories of 7-night accelerometer-measured sleep duration SD
- Outcome
- Incident diabetes (medical records, death register and/or self-reported diagnosis)
- Follow-up
- 7 years
Methodological detailsUK Biobank, accelerometer-measured sleep
- UK Biobank
- Accelerometer-measured sleep
Main finding
As reported in the abstract
Incident diabetes
Each group vs ≤30 minHazard ratio (95% CI)
31-45 min
1.15(0.99–1.33)
46-60 min
1.28(1.10–1.48)
61-90 min
1.54(1.32–1.80)
≥91 min
1.59(1.33–1.90)
- Incident diabetes cases
- 2,058
- Person-years of follow-up
- 622,080
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Sleep duration SD >60vs ≤60 min, further adjusted for lifestyle, comorbidities, environmental factors and adiposityAssociation attenuated | 1.11 (1.01–1.22) | |
| 0.512Hazard ratio (log scale) |
| Outcome | Higher diabetes risk (95% CI) | P value |
|---|---|---|
| Nonlinear relationship; sleep duration SD >60 vs ≤60 minAdjusted for age, sex, and race | 34% (1.22–1.47) | P nonlinearity 0.0002 |
Effect modification
- Stronger association with lower diabetes polygenic risk score (PRS) (P interaction ≤ 0.0264)
- Stronger association with longer sleep duration (P interaction ≤ 0.0009)
Original publication
Association Between Accelerometer-Measured Irregular Sleep Duration and Type 2 Diabetes Risk: A Prospective Cohort Study in the UK Biobank. Diabetes Care. Published 17 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →