The Use of Semaglutide in Patients With Renal Failure-A Retrospective Cohort Study
Authors' conclusion
Based on this retrospective study semaglutide appears to be tolerated by most individuals with CKD 4 or greater despite associated gastrointestinal side effects similar to those observed in patients with better kidney function and leads to an improvement of glycemic control and insulin discontinuation in patients with T2DM. Modest weight loss (approximately 4.6% of the total body weight) was observed on the prescribed doses. Larger prospective randomized studies are needed to comprehensively assess the risks and benefits of semaglutide in patients with CKD 4 or greater and obesity.
Study context
- Population
- Patients with chronic kidney disease (CKD) 4 or greater (estimated glomerular filtration rate (eGFR) 15–29 or <15 mL/min/1.73 m², or on dialysis) started on semaglutide, January 2018–January 2023; 96.0% T2D, 53.9% male, mean age 66.8 y (SD 11.5), mean BMI 36.2 (SD 7.5)
- Participants
- 76 patients
- Outcome
- Safety and efficacy of semaglutide
Methodological detailssingle-group, electronic medical record based, consecutive patients
- Single-group
- Electronic medical record based
- Consecutive patients
Main finding
As reported in the abstract
- No adverse effects reported
- 48 (63.1%)
- Mean weight decreased from 106.2 (SD 24.2) to 101.3 (SD 27.3) kg
- P < .001
- Mean hemoglobin A1c (HbA1c) decreased from 8.0% (SD 1.7) to 7.1% (SD 1.3)
- P < .001
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Insulin discontinuation after starting semaglutide (T2D) | Semaglutide 16% |
| Duration of semaglutide treatment | Semaglutide median 17.4 (IQR 0.43–48.8) months |
Maximum prescribed dose
- 1 mg injectable
- 28 (45.2%)
- 14 mg oral
- 2 (14.2%)
Safety
Semaglutide discontinuation
- Adverse effects as primary reason for discontinuation
- 37.0%
- Most common complaints: nausea, vomiting and abdominal pain
Original publication
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