Lipids & metabolic liver disease
Association Between Serum Remnant Cholesterol Level and Metabolic Dysfunction-associated Steatotic Liver Histology
Authors' conclusion
High serum Rem-C levels were associated with high NAS but not with fibrosis stage, particularly in men. Controlling serum Rem-C level may improve MASLD activity.
Study context
- Population
- Patients aged 20–80 with biopsy-diagnosed MASLD (94 men, 128 women)94 men · 128 women
- Participants
- 222 patients
- Exposure
- Serum remnant cholesterol (Rem-C) levels across MASLD histological categories
- Outcome
- Relationship between accurately measured serum Rem-C levels and histological findings of MASLD
Methodological detailssingle-center, observational
- Single-center
- Observational
Main finding
As reported in the abstract
- Rem-C significantly higher with NAFLD activity score (NAS) 5 to 8 vs 1 to 4, >66% vs <33% steatosis, lobular inflammation ≥5 vs <2 foci, and many/prominent vs few ballooning cells
- No significant association between Rem-C and advanced fibrosis (univariate)
- Significant association between Rem-C and NAS, remaining significant in multivariate analysis adjusted for confounders
Observational data: associations, not effects.
Further findings
Analysis by sex
- Relationships significant in men but not in women
Original publication
Association Between Serum Remnant Cholesterol Level and Metabolic Dysfunction-associated Steatotic Liver Histology. J Clin Endocrinol Metab. Published 28 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →