Lipids & metabolic liver disease
Epicardial and liver fat implications in albuminuria: a retrospective study
Authors' conclusion
Identification and management/decrease of excess adiposity must be a target in the primary and secondary prevention of chronic kidney disease development and progression. Visceral adiposity assessment may be an adequate target in the daily clinical setting. Moreover, epicardial adipose tissue and steatotic liver disease assessment may aid in the primary prevention of renal dysfunction.
Study context
- Population
- Patients with EAT and SLD assessed by CT
- Participants
- 181 patients
- Exposure
- SLD and excess EAT vs their absence
- Outcome
- Presence of albuminuria at follow-up
- Follow-up
- Median 11.2 years
Methodological detailslong-term longitudinal
- Long-term longitudinal
Main finding
As reported in the abstract
Albuminuria
Hazard ratio (95% CI)P value
SLDadjusted for visceral adipose tissue, sex, age, weight status, T2D, prediabetes, hypertriglyceridemia, hypercholesterolemia, arterial hypertension, CV prevention treatment
3.15(1.20–8.26)
P = 0.02Excess EATadjusted for visceral adipose tissue, sex, age, weight status, T2D, prediabetes, hypertriglyceridemia, hypercholesterolemia, arterial hypertension, CV prevention treatment
6.12(1.69–22.19)
P = 0.006SLD + excess EATvs SLD alone
5.91(1.15–30.41)
P = 0.033Observational data: associations, not effects.
Further findings
Liver steatosis and abnormal EAT by visceral adipose tissue tertile
- Proportion with liver steatosis and abnormal EAT significantly higher in second and third tertile vs first tertile
Correlation between epicardial fat and SLD
- Rho
- 0.43 (p < 0.001)
Original publication
Epicardial and liver fat implications in albuminuria: a retrospective study. Cardiovasc Diabetol. Published 22 August 2024. doi:10.
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