Lipids & metabolic liver disease
Metabolic Dysfunction-associated Steatotic Liver Disease Alters Fatty Acid Profiles in the Liver and Adipose Tissue
Authors' conclusion
Patients with MASH exhibited reduced hepatic PUFA content, increased hepatic saturated FAs, and a higher n6-to-n3 PUFA ratio, whereas no clear trends were observed in adipose tissue. These findings highlight distinct differences in FA metabolism between the liver and adipose tissue in MASLD, emphasizing tissue-specific regulatory mechanisms.
Study context
- Population
- Patients with severe obesity undergoing laparoscopic gastric bypass surgery; 122 women, mean age 46.9 ± 9.7 years, BMI 43.5 ± 5.7 kg/m²
- Participants
- 183 patients
- Exposure
- Fatty acid (FA) profiles in normal liver vs simple steatosis vs MASH
- Outcome
- FA proportions in liver, serum, visceral and subcutaneous adipose tissue
Methodological detailsFA composition by gas-liquid chromatography; Kruskal-Wallis test
- FA composition by gas-liquid chromatography; Kruskal-Wallis test
Main finding
As reported in the abstract
- FA proportions varied more in liver than in adipose tissue in MASH
- MASH vs Normal liver: all adjusted P < .01
- MASH vs Normal liver: all adjusted P < .001
Observational data: associations, not effects.
Original publication
Metabolic Dysfunction-associated Steatotic Liver Disease Alters Fatty Acid Profiles in the Liver and Adipose Tissue. J Clin Endocrinol Metab. Published 12 June 2025. doi:10.
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