Lipids & metabolic liver disease
Independent and joint relationships of cardiorespiratory fitness and body mass index with liver fat content
Authors' conclusion
There was a significant negative association between CRF and LFC, and this association was independent of BMI. The results of this study strongly recommend improving CRF to mitigate LFC.
Study context
- Population
- Community-based UK Biobank participants; mean age 55.57 years; Cardiorespiratory fitness (CRF) by bicycle ergometer, liver fat content (LFC) by MRI liver proton density fat fraction (PDFF)
- Participants
- 5,765 participants
- Exposure
- Highest vs lowest PWC75% tertile
- Outcome
- Absolute reduction and percentage change in liver PDFF (%)
- Follow-up
- Median (range) 10.7 (4.0-17.7) years
Methodological detailsUK Biobank, community-based
- UK Biobank
- Community-based
Main finding
As reported in the abstract
Liver PDFF
Each group vs lowest PWC75% tertileEstimate (95% CI)
Highest PWC75% tertile
absolute reduction in PDFF −0.450(−0.699 to −0.192)
Highest PWC75% tertile
percentage change in PDFF −4.152(−6.044 to −2.104)
Observational data: associations, not effects.
Further findings
CRF–LFC association by BMI category
- Largest absolute reduction in LFC with obesity; largest percentage change with normal weight
- P for interaction < 0.001
Joint analysis of PWC75% and BMI
- Negative dose-response relationship of PWC75% and BMI with PDFF
Sex and age subgroups
- Associations consistent across sex and age subgroups
- P for interaction > 0.05
Original publication
Independent and joint relationships of cardiorespiratory fitness and body mass index with liver fat content. Diabetes Obes Metab. Published 20 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →