Lipids & metabolic liver disease
Closer Association of Liver Stiffness Than Liver Fat Content With Imaging‐Derived Neurovascular Coupling in a Metabolic Dysfunction‐Associated Steatotic Liver Disease Cohort
Authors' conclusion
Within this cohort and the observed PDFF range, MRE-derived liver stiffness was more closely associated with imaging-derived NVC surrogate measures than liver fat content in MASLD.
Study context
- Population
- MASLD patients and age- and education-matched healthy controls; liver stiffness by MR elastography (MRE) and fat content by MRI-PDFF98 MASLD, 32 healthy controls (HCs)
- Participants
- 130 patients
- Exposure
- MASLD_high vs MASLD_low vs HCs
- HCsn = 32reference
- Outcome
- Association of liver stiffness vs liver fat content with resting-state CBF-ReHo surrogate measures of imaging-derived neurovascular coupling (NVC)
Methodological detailsage- and education-matched healthy controls, multi-modal MRI, exploratory mediation analysis
- Age- and education-matched healthy controls
- Multi-modal MRI
- Exploratory mediation analysis
Main finding
As reported in the abstract
Imaging-derived NVC (CBF-ReHo coupling, CBF/ReHo ratios)
- MASLD_high showed reduced global CBF-ReHo coupling and altered cerebral blood flow (CBF)/regional homogeneity (ReHo) ratios vs HCs and MASLD_low, mainly bilateral superior temporal pole/superior temporal gyrus (TPOsup)
- Liver stiffness: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Estimate |
|---|---|
| Exploratory mediation: indirect association of hepatocellular injury markers with TPOsup CBF/ReHo ratios via MRE-derived liver stiffnessExploratory | (95% CI 0.0795–0.2790) |
Original publication
Closer Association of Liver Stiffness Than Liver Fat Content With Imaging‐Derived Neurovascular Coupling in a Metabolic Dysfunction‐Associated Steatotic Liver Disease Cohort. Diabetes Obes Metab. Published 22 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →