Lipids & metabolic liver disease
Sex- and menopause-specific inverse associations between metabolic dysfunction–associated steatotic liver disease and serum lipoprotein(a) concentrations: evidence from SHIP and UK Biobank
Authors' conclusion
Our findings from two large community-based studies show that MASLD and higher LFC and ALT values were independently associated with lower Lp(a) concentrations in postmenopausal females and males.
Study context
- Population
- Community-based adults: SHIP-START-0 aged 32 to 70 years (1961 females; 51.3%); UK Biobank aged 38 to 72 years (14,926 females; 52.4%)3,825 SHIP + 28,504 UK Biobank
- Exposure
- MASLD, liver fat content and transaminases vs Lp concentrations
- Outcome
- Serum Lp(a) concentrations
Methodological detailstwo community-based cohorts (SHIP-START-0 and UK Biobank), sex- and menopausal status-stratified analyses, adjusted for age, BMI, HbA1c, glucose-lowering medication use, hypertension, smoking and alcohol consumption
- Two community-based cohorts (SHIP-START-0 and UK Biobank)
- Sex- and menopausal status-stratified analyses
- Adjusted for age, BMI, HbA1c, glucose-lowering medication use, hypertension, smoking and alcohol consumption
Main finding
As reported in the abstract
Associations of MASLD, LFC and liver enzymes with Lp(a), by sex and menopausal status
Males with vs without MASLD: lower Lp(a), SHIP-START-0
24%
Males with vs without MASLD: lower Lp(a), UK Biobank
9%
Observational data: associations, not effects.
Original publication
Sex- and menopause-specific inverse associations between metabolic dysfunction–associated steatotic liver disease and serum lipoprotein(a) concentrations: evidence from SHIP and UK Biobank. Cardiovasc Diabetol. Published 12 July 2026. doi:10.
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